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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKACA
All Species:
38.48
Human Site:
Y123
Identified Species:
76.97
UniProt:
P17612
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17612
NP_002721.1
351
40590
Y123
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
Chimpanzee
Pan troglodytes
XP_001171437
427
49115
Y199
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
Rhesus Macaque
Macaca mulatta
O62846
209
24077
Dog
Lupus familis
XP_867543
351
40605
Y123
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
Cat
Felis silvestris
Mouse
Mus musculus
P05132
351
40552
Y123
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
Rat
Rattus norvegicus
P27791
351
40601
Y123
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422379
398
45968
Y170
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
Frog
Xenopus laevis
Q6GPN6
434
49096
Y181
R
L
Y
F
I
L
D
Y
I
N
G
G
E
L
F
Zebra Danio
Brachydanio rerio
Q7ZTW4
433
48964
Y180
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P12370
353
40820
Y125
N
L
Y
M
V
L
E
Y
V
P
G
G
E
M
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P21137
404
46327
F160
N
L
Y
M
V
L
E
F
I
S
G
G
E
M
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P06245
380
44201
Y149
N
I
F
M
V
M
D
Y
I
E
G
G
E
L
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.5
51.2
93.1
N.A.
98
98
N.A.
N.A.
81.4
35.2
34.8
N.A.
82.4
N.A.
68.5
N.A.
Protein Similarity:
100
81.9
56.7
95.4
N.A.
99.4
99.1
N.A.
N.A.
84.6
54.1
53.1
N.A.
90
N.A.
78.4
N.A.
P-Site Identity:
100
100
0
100
N.A.
93.3
100
N.A.
N.A.
100
46.6
53.3
N.A.
93.3
N.A.
73.3
N.A.
P-Site Similarity:
100
100
0
100
N.A.
93.3
100
N.A.
N.A.
100
80
80
N.A.
100
N.A.
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
45.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
67.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
93.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
25
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
67
0
0
9
0
0
92
0
0
% E
% Phe:
0
0
9
17
0
0
0
9
0
0
0
0
0
0
92
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
92
92
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
9
0
0
0
34
0
0
0
0
0
0
% I
% Lys:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
84
0
0
0
34
0
0
0
0
0
0
0
25
0
% L
% Met:
0
0
0
75
0
59
0
0
0
0
0
0
0
67
0
% M
% Asn:
75
0
0
0
0
0
0
0
0
17
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
50
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
84
0
0
0
59
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
84
0
0
0
0
84
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _